Celiac disease may be complicated by symptoms that raise the suspicion of small-intestinal malignancy. The objective is to evaluate wireless capsule endoscopy in complicated celiac disease.
Dr Culliford and colleagues conducted a prospective study at a university referral center including 47 patients.
The researchers reported that the indications for wireless capsule endoscopy were abdominal pain occurring in 57%, and cancer surveillance noted in 23% of patients.
|Findings were consistent with celiac disease in 87%|
Wireless endoscopy was also performed where the team identified blood in the stool, or persistent iron deficiency.
The research team noted that findings were consistent with celiac disease in 87%, where 68% had atrophy, 62% had fissuring , and 19% with mosaic pattern, extending to the ileum in 34%.
Unexpected results included ulceration, cancer, polyps, stricture, submucosal mass, ulcerated nodular mucosa, and intussusception observed in the patients.
Dr Culliford' team concluded, “Wireless capsule endocsopy has a high yield in complicated celiac disease, by identifying mucosal abnormalities and by excluding adenocarcinoma.”