Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 18 November 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

High rate of ileo-colonic lymphoid nodular hyperplasia in autism

Ileo-colonic lymphoid nodular hyperplasia is a characteristic pathological finding in children with ASD and gastrointestinal symptoms, reports the most recent issue of the European Journal of Gastroenterology & Hepatology.

News image

fiogf49gjkf04

Intestinal mucosal pathology is characterized by ileo-colonic lymphoid nodular hyperplasia, mild acute and chronic inflammation of the colorectum, small bowel and stomach.

It has been reported in children with autistic spectrum disorder.

Dr Andrew Wakefield and colleagues assessed ileo-colonic lymphoid nodular hyperplasia in autistic spectrum disorder and control children.

The research team tested the hypothesis that there is an association between ileo-colonic lymphoid nodular hyperplasia and autistic spectrum disorder in children.

The team included 148 consecutive children with autistic spectrum disorder, of which 127 were male with gastrointestinal symptoms with a median age of 6 years.

Gastrointestinal symptoms were investigated by ileo-colonoscopy.

The researchers scored and compared macroscopic and histological features of different groups.

Ileal lymphoid nodular hyperplasia occurred in 90% with autistic spectrum disorder vs 30% in controls
European Journal of Gastroenterology & Hepatology

Group 1 included 30 developmentally normal controls, of which 25 were males with median age of 7 years with no inflammatory bowel disease or celiac disease.

The team reported that Group 2 included 16 cases showing mild non-specific colitis, of which 13 were male.

Group 3 included 14 cases with normal colonic histology, of which 12 were male.

The researchers reported that from these groups, 74 children with autistic spectrum disorder and 23 controls underwent upper gastrointestinal endoscopy.

The influence on ileal lymphoid nodular hyperplasia of dietary restriction, and age at colonoscopy was examined.

In addition, the team examined co-existent lymphoid nodular hyperplasia elsewhere in the intestine.

The researchers found that the prevalence of lymphoid nodular hyperplasia in the ileum was 90% with autistic spectrum disorder compared with 30% controls.

Lymphoid nodular hyperplasia in the colon occurred more often in the group with autistic spectrum disorder, at 59% versus controls at 23%.

The researchers found that these results persisted whether or not controls had co-existent colonic inflammation.

The severity of ileal lymphoid nodular hyperplasia was significantly greater in children with autistic spectrum disorder compared with controls.

The research team observed that moderate to severe ileal lymphoid nodular hyperplasia was present in 68% of children with autism versus 15% in controls .

The team noted that severe ileal lymphoid nodular hyperplasia was associated with co-existent colonic lymphoid nodular hyperplasia in children with autism.

However, the presence and severity of ileal lymphoid nodular hyperplasia was not influenced by either diet or age at colonoscopy.

The team noted that isolated ileal lymphoid nodular hyperplasia without evidence of pathology elsewhere in the intestine occurred in less than 3% of children.

On histopathological examination, hyperplastic lymphoid follicles were found to be more prevalent in the ileum of children with autistic spectrum disorder versus controls.

Dr Wakefield's team concluded, “Ileo-colonic lymphoid nodular hyperplasia is a characteristic pathological finding in children with autistic spectrum disorder and gastrointestinal symptoms.”

“It is associated with mucosal inflammation, and differences in age at colonoscopy and diet do not account for these changes.”

“The data support the hypothesis that lymphoid nodular hyperplasia is a significant pathological finding in children with autistic spectrum disorder.”

Eur J Gastroenterol & Hepatol 2005: 17(8): 827-36
13 July 2005

Go to top of page Email this page Email this page to a colleague

 17 November 2017 
Food elimination diets for treatment of adults with eosinophilic esophagitis
 17 November 2017 
PPI use and cognitive function in women
 17 November 2017 
Predicting microscopic colitis
 16 November 2017 
NAFLD-hepatocellular carcinoma and survival after orthotopic liver transplant
 16 November 2017 
Prepregnancy obesity and severe maternal morbidity
 16 November 2017 
Celiac disease screening in adult first-degree relatives
 15 November 2017 
Breastfeeding and the risk of IBD
 15 November 2017 
Medication nonadherence and health care costs
 15 November 2017 
Predicting recurrence after curative rectal cancer surgery
 14 November 2017 
HBV/HCV coinfection and cirrhosis
 14 November 2017 
Sexual dysfunction after rectal cancer surgery
 14 November 2017 
Eosinophilic gastroenteritis and colitis
 13 November 2017 
GI bleeding in patients taking non–vitamin K antagonist oral anticoagulants
 13 November 2017 
Genetic polymorphisms, fatty acids and ulcerative colitis
 13 November 2017 
Flares after immunomodulator withdrawal in Crohn's
 10 November 2017 
Thiopurines vs TNF and lymphoma risk in IBD
 10 November 2017 
Drug monitoring of anti-tumour necrosis factor therapy in IBD
 10 November 2017 
Treatment decisions for older patients with colorectal cancer
 09 November 2017 
Quality standards in upper gastrointestinal endoscopy
 09 November 2017 
Irradiated rectal cancer and chemoradiotherapy
 09 November 2017 
Environmental factors and IBD
 08 November 2017 
Prophylaxis of spontaneous bacterial peritonitis
 08 November 2017 
Socioeconomic characteristics in diverticular disease
 08 November 2017 
Optimal management of postoperative Crohn's disease
 07 November 2017 
Community Screening for Helicobacter pylori
 07 November 2017 
Early readmission in IBD patients
 07 November 2017 
Mesocolic excision for colon cancer
 06 November 2017 
Food elimination diet for children with eosinophilic esophagitis
 06 November 2017 
Biologic agents and obesity in children with IBD
 06 November 2017 
Liver cancer burden despite extensive use of antiviral agents
 03 November 2017 
Statins and mortality in chronic viral hepatitis
 03 November 2017 
Propofol for outpatient colonoscopy
 03 November 2017 
Asthma and IBD development
 02 November 2017 
Diverticulitis and emergency department burden
 02 November 2017 
Rural residence and risk of IBD
 02 November 2017 
Sexual functioning in Hep C
 01 November 2017 
Heartburn relief in adolescents with GERD
 01 November 2017 
Barriers to hepatitis C treatment
 01 November 2017 
Autoimmune pancreatitis in children
 31 October 2017 
Surveillance in ulcerative colitis and Crohn’s disease
 31 October 2017 
Endoscopic indices of disease activity for Crohn’s
 31 October 2017 
Follow-up of positive results on fecal blood tests
 30 October 2017 
Local recurrence after curative rectal cancer surgery
 30 October 2017 
Low-flow ascites pump in refractory cirrhosis
 30 October 2017 
Medical therapy of patients with pediatric-onset IBD
 27 October 2017 
NAFLD in advanced fibrosis in the USA
 27 October 2017 
Early readmission in cirrhosis after bacterial infections
 26 October 2017 
Predicting response to anti-TNF therapy in Crohn's
 26 October 2017 
Conversion to open laparotomy in rectal cancer
 25 October 2017 
Conversion of colonoscopy to sigmoidoscopy
 25 October 2017 
Fecal microbiota transplantation
 25 October 2017 
Rifaximin and survival in hepatic encephalopathy
 24 October 2017 
Eosinophilic esophagitis with swallowed topical corticosteroids
 24 October 2017 
Meta-analysis in nutritiona research
 23 October 2017 
NAFLD-related hepatocellular carcinoma in liver resection
 23 October 2017 
Outcome of hepatic sarcoidosis
 20 October 2017 
Hospital readmissions reduction program
 20 October 2017 
Conversion of planned colonoscopy to sigmoidoscopy
 19 October 2017 
Fecal immunochemical tests in colorectal cancer screening
 19 October 2017 
Current management of chylous ascites

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us