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 20 November 2017

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News

Gastric cancer alarm symptoms significant for prognosis

Alarm symptoms are absent in a minority of patients with gastric cancer at diagnosis, who have a better chance of curative surgery and long-term survival than those with alarm symptoms, finds the most recent British Journal of Surgery.

News image

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Dr Stephens and colleagues determined the incidence and spectrum of alarm symptoms in patients with newly diagnosed gastric cancer.

The research team examined the relationship between symptoms and outcome.

The team prospectively studied 300 consecutive patients with gastric adenocarcinoma.

Survival rate at 5 years is 38% for patients without alarm symptoms vs 15% for those with
British Journal of Surgery

The researchers compared outcomes of 40 patients without alarm symptoms with those of the 260 patients with alarm symptoms.

The team reported the possibility of performing an R0 gastrectomy more often in patients without alarm symptoms, at a rate of 52%.

R0 gastrectomy was only possilbe in 27% of patients with alarm symptoms or 27%.

The researchers noted that the cumulative survival rate at 5 years was 38% for patients without alarm symptoms versus 15% for those with alarm symptoms.

In a multivariate analysis, the team found that distant metastasis and overall stage of cancer were independently associated with length of survival.

The researchers also found that persistent vomiting at diagnosis was independently associated with length of survival.

Dr Stephen's team concludes, “Alarm symptoms are absent in a significant minority of patients with gastric cancer at diagnosis.”

“These patients stand a better chance of curative surgery and long-term survival than those with alarm symptoms.”

Br J Surg 2005: 92(7): 840-6
23 June 2005

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