Proton-pump inhibitors effectively suppress stomach acidity.
They are widely used for treating gastro-oesophageal reflux disease and related conditions.
While generally safe, omeprazole and other proton-pump inhibitors can delay gastric emptying.
Dr Rojavin and colleagues tested the hypothesis that tegaserod can normalize or prevent omeprazole-induced delay in gastric emptying.
| Omeprazole delays time to gastric retention of the meal at 60 and 120 min after its ingestion|
|Alimentary Pharmacology & Therapeutics|
The researchers conducted a randomized, double-blind, placebo-controlled, parallel group study in 40 healthy male volunteers.
After obtaining informed consent and screening, the team treated eligible volunteers with unblinded omeprazole 20 mg b.d.
The volunteers were also treated with either blinded tegaserod 6 mg t.d.s. as the active treatment group or placebo-matching tegaserod t.d.s. as the control group for 14 days.
The research team assessed gastric emptying before and after treatment, using a scintigraphy method.
The team found that omeprazole monotherapy significantly delayed gastric emptying expressed by duration of lag-phase.
The researchers noted that omeprazole also delayed time to gastric half-emptying, and gastric retention of the meal at 60 and 120 min after its ingestion.
In addition, the researchers observed that tegaserod taken together with omeprazole effectively prevented development of the above effects.
Combined treatment was safe and well tolerated.
Dr Rojavin and team concludes, “Concomitant administration of tegaserod 6 mg t.d.s. prevented development of the delayed gastric emptying induced by omeprazole monotherapy.”