Type 2 diabetes mellitus might increase the risk of colorectal cancer on the basis of chronic hyperinsulinemia and hyperglycemia.
However, epidemiologic evidence for this association is inconclusive.
Dr Yang and colleagues conducted a population-based study to clarify this association.
|10,447 patients with colorectal cancer from the UK General Practice Research Database are analyzed|
|Clinical Gastroenterology and Hepatology|
The research team conducted a case-control study using the United Kingdom General Practice Research Database.
The researchers included cases of 10,447 patients with incident colorectal cancer diagnoses.
The team selected up to 10 control subjects for each case, matching on year of birth, enrollment date, and duration of database follow-up.
The exposure of interest was type 2 diabetes mellitus and odds ratios were calculated by using conditional logistic regression.
The researchers found that a prior diagnosis of type 2 diabetes mellitus was associated with a modestly increased risk of colorectal cancer.
The team observed an association between type 2 diabetes mellitus and colorectal cancer in both men and women.
Furthermore, the researchers noted an increased risk in both colon and rectal cancers.
Dr Yang's team concludes, “Type 2 diabetes mellitus is associated with an increased risk of colorectal cancer.”
“The risk increase is present in both sexes, as well as in both colonic and rectal cancers.”