Chronic Hepatitis B and C are commonly associated with hepatic steatosis.
Dr Roberts and colleagues investigated predictors of hepatic steatosis, and their impact on inflammation and fibrosis in chronic Hepatitis B and C.
The researchers included consecutive patients with either chronic Hepatitis or C who had a liver biopsy at The Alfred Hospital in 2002.
| Alcohol intake and age are predictors of hepatic fibrosis|
|Journal of Hepatology|
The histological analysis of liver biopsies was performed by 2 hepatopathologists blinded to the clinical data.
The research team analyzed 91 patients including 17 patients with chronic Hepatitis B and 74 with chronic Hepatitis C.
The team found that chronic Hepatitis C genotype 3, C-peptide, glucose and waist circumference were independent predictors of extent of Brunt steatosis grade.
The team also found that chronic Hepatitis C genotype 3, C-peptide and waist circumference were independent predictors of microvesicular steatosis grade.
The researchers observed that alcohol intake and age were predictors of hepatic fibrosis.
The team identified a trend in correlation between Brunt steatosis and microvesicular steatosis grades, and fibrosis progression rate in chronic Hepatitis C genotype non-3.
Dr Robert's team concludes, “Hepatic steatosis is common in chronic Hepatitis B and C.”
“Hepatic steatosis is associated with waist circumference, glucose, C-peptide and chronic Hepatitis C genotype 3.”
“Steatosis grade appears to relate to hepatic fibrosis progression rate in chronic Hepatitis C genotype non-3.”