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 23 May 2018

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News

Endoscopic pyloric injection for refractory gastroparesis

Male gender was associated with a response to this therapy; however, durability of response was unrelated to gender, and vomiting as a major symptom predicted no response, finds the latest issue of Gastrointestinal Endoscopy.

News image

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Botulinum toxin A injected into the pyloric sphincter has been reported in small case series to treat gastroparesis.

Dr Friedenberg and colleagues from Florida studied the use of this treatment in a large number of patients with gastroparesis.

43% had a response to botulinum toxin treatment lasting a mean of 5 months
Gastrointestinal Endoscopy

The researchers identified patients who underwent pyloric botulinum injection for treatment of gastroparesis.

The research team defined response as improvement or resolution of the patient's major symptom and/or two minor symptoms for 4 weeks.

The researchers reported that of 115 patients treated, 63 patients met the study criteria.

The patients included 53 women and 10 men with a mean age of 42 years, and most patients had idiopathic gastroparesis.

The researchers noted that 43% of patients experienced a symptomatic response to treatment.

The team used stepwise logistic regression, and found that male gender was associated with response to treatment.

The researchers also observed that vomiting as a major symptom was associated with a lack of response.

At 3 months follow-up, the mean duration of response for those patients responding was 5 months for women and 4 months for men.

The researchers noted that the corresponding medians were 5 or interquartile ranges of 3 to 6 for females, respectively, and medians were 4 or interquartile ranges at 3 to 4 for males, respectively.

Dr Friedenberg concludes, “Of the patients, 43% had a response to botulinum toxin treatment that lasted a mean of approximately 5 months.”

“Male gender was associated with a response to this therapy; however, durability of response was unrelated to gender.”

“Vomiting as a major symptom predicted no response.”

Gastrointest Endosc 2005: 61(7): 833
13 June 2005

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