Helicobacter pylori is the major cause of chronic gastritis, and a risk factor for peptic ulcer and gastric cancer.
Dr Korpela and colleagues from Finland investigated the effect of probiotic supplementation on the tolerance and efficacy of H pylori eradication treatment in a randomized, double-blind, placebo-controlled trial.
|The probiotic group had less treatment-related symptoms throughout H pylori eradication therapy|
|Alimentary Pharmacology and Therapeutics|
The researchers screened a total of 338 volunteers for H pylori infection.
The team reported that the eligibility criteria were met by 47 subjects whose H pylori infection was verified at the outset.
The researchers re-evaluated H pylori infection after the treatment by the 13C-urea breath test and by enzyme immunoassay serology.
The research team randomized the subjects to receive probiotic therapy consisting of Lactobacillus rhamnosus GG, L rhamnosus LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp shermanii JS.
The researchers also randomized subjects to placebo during H pylori eradication and for 3 weeks following the treatment, and recorded their daily symptoms in a standardized diary.
The team evaluated the frequencies of new or aggravated symptoms, and found no significant differences between the 2 groups for individual symptoms.
However, the probiotic group showed less treatment-related symptoms as measured by the total symptom score change throughout the H pylori eradication therapy in contrast to the placebo group.
The investigators observed that the H pylori eradication rate was non-significantly higher in the group receiving probiotic therapy.
In the group receiving probiotic therapy, the recovery of probiotic bacteria in the faeces increased significantly.
Dr Korpela's team concluded, “In this pilot study, probiotic supplementation did not diminish significantly the frequency of new or aggravated symptoms during H pylori eradication.”
“However, our data suggest an improved tolerance to the eradication treatment when total symptom severity was taken into account.”
“Furthermore, the results show that probiotic bacteria are able to survive in the gastrointestinal tract despite the intensive antimicrobial therapy.”