Dr Salmon-Cerona and colleagues analyzed the characteristics of HIV infected patients who died from liver disease, focusing on hepatitis virus co-infection.
The research team reported that 185 French hospital departments involved in HIV/AIDS management prospectively notified all deaths occurring in 2000.
The team classified patients whose Hepatitis C and Hepatitis B serostatus was known.
|The main causes of death for HIV-Hep C co-infections is liver disease at 31%|
|Journal of Hepatology|
The researchers classified the patients into 4 groups as being infected by Hepatitis C alone, Hepatits B alone, both Hepatitis C and Hepatitis B, or neither.
The team found that among 822 HIV infected patients, 29% were infected by Hepatitis C alone, 8% by Hepatitis B alone, and 4% by both Hepatits C and Hepatitis B.
The researchers noted that the most frequent causes of death were liver disease at 31% of cases and AIDS at 29% among HIV–Hepatitis C co-infected patients.
The team observed that the causes of death among HIV-Hepatitis B co-infected patients were AIDS at 38% and liver disease at 22%.
Liver disease was a more frequent cause of .death among patients co-infected by both Hepatitis C and Hepatitis B with 44% of cases.
The research team reported that hepatocellular carcinoma was present in 15% of patients who died from liver disease, and was associated with Hepatitis B co-infection.
Nearly half the patients who died from liver disease had more than 200 CD4/mm3.
Dr Salmon-Cerona concludes, “Liver disease is now a leading cause of death among HIV-Hepatitis C co-infected patients and is becoming an important cause of death among HIV-Hepatits B co-infected patients.”
“The risk of death from liver disease is highest in patients co-infected by both Hepatitis C and Hepatitis B.”