Dr Haapalahti and colleagues described the nutritional status in patients with screen-detected celiac disease.
The investigative team assessed nutritional status by serum tests and anthropometric measures in 26 subjects of 16 to 25 years of age with biopsy-proven celiac disease.
The team also assessed 29 healthy control subjects between 16 to 21 years of age with negative tissue transglutaminase antibodies.
| Iron status was subnormal in 30 % of these patients versus 14 % of controls|
|Journal of Pediatric Gastroenterology and Nutrition|
All the subjects were selected from the cohort of 3654 schoolchildren.
The team noted that compared with control subjects, celiac disease patients had lower median values of whole blood folic acid of 91 nmol versus 109 nmol.
Patients with celiac disease also had lower serum ferritin compared with controls at 14 g/L versus 27 g/L and lower pre-albumin of 0.21 g/L versus 0.28 g/L.
The researchers reported that patients with celiac disease as compared with controls had higher transferrin receptor index of 1.3 versus 1.1.
The team also noted that serum transferrin receptor-ferritin index in these patients was 1.2 compared with 0.7 in controls.
Folic acid concentration was subnormal in 31 % of the subjects with celiac disease versus 14 % of the controls.
The researchers found that iron status measured as transferrin receptor-ferritin index was subnormal in 30 % of these patients versus 14 % of controls.
The investigators observed that body mass index was not different in females with celiac disease and control groups or in the males of the respective groups.
Females with celiac disease were shorter than the controls, but no difference was found in males.
The researchers found no association between the nutritional status and the markers of mucosal injury.
The team reported that titer of transglutaminase was associated with whole blood folic acid and with transferrin receptor-ferritin index.
Dr Haapalahti concludes, “One third of screen-detected adolescent subjects with celiac disease have abnormalities in folate or iron status that call for early diagnosis and dietary treatment of the disease to prevent nutritional deficiencies.”