Fatigue, which may have a significant impact on quality of life, is the most common reported symptom in primary biliary cirrhosis.
Multiple instruments to quantify fatigue and quality of life in liver disease have been validated, but have not been broadly applied to primary biliary cirrhosis patients from the U.S.
Dr Odin and colleagues from New York examined the extent of fatigue and its effect on quality of life in primary biliary cirrhosis patients from the U.S.
The researchers administered 2 validated questionnaires about quality of life from the Mayo version of the National Institute of Diabetes and Digestive and Kidney Diseases-QA, and about fatigue from the Fisk Fatigue Impact Score.
U.S. primary biliary cirrhosis patients
have less fatigue than non-U.S. primary biliary cirrhosis patients |
|American Journal of Gastroenterology|
A proposed physical measure of fatigue in primary biliary cirrhosis involving the grip strength test was also administered to patients on the day of routine physician visit.
The questionnaires and physical measure were administered to 70 patients with primary biliary cirrhosis and a on the day of routine physician visit.
The investigators employed nonparametric methods for the analysis.
The research team reported that the fatigue and quality of life domain scores included physical functioning, liver symptoms, health satisfaction and the Karnofsky index.
The team found that the fatigue and quality of life tests discriminated between patients with and without self-reported fatigue, as opposed to the grip strength results.
Fatigue and quality of life domains were also found to correlate strongly with each other and not with the grip strength results.
The investigators observed that neither quality of life nor fatigue scores correlated with age.
Dr Odin’s team concluded, “The correlation between fatigue and quality of life scores suggests fatigue has an impact on quality of life in primary biliary cirrhosis patients.”
“However, our fatigue scores suggest that primary biliary cirrhosis patients from the U.S. have less fatigue than non-U.S. primary biliary cirrhosis patients.”
“The grip strength is an insensitive measure of fatigue in U.S. primary biliary cirrhosis patients.”