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News

Diagnostic performance with polyethylene glycol for endoscopy

Polyethylene glycol preparation does not improve the quality of capsule endoscopy images or its diagnostic performance, and tends to increase gastric emptying time, finds the recently published Journal of Clinical Gastroenterology.

News image

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Small bowel contents can sometimes hamper the quality of capsule images.

Dr Ben-Soussan and colleagues investigated the effect of polyethylene glycol preparation administered prior to capsule endoscopy upon quality of images, gastrointestinal transit time, and detection rate of small bowel bleeding lesions in patients with obscure gastrointestinal bleeding.

The research team included 42 consecutive patients where the first 16 patients (Group A) received no preparation and the following 27 patients (Group B) received 2 L of polyethylene glycol preparation the night before.

The investigators performed capsule endoscopy following a 12 hour fasting period.

The quality of images in the duodenojejunum and ileum were not different between the groups
Journal of Clinical Gastroenterology

The quality of images was assessed by the team at both in duodenojejunum and ileum level, using a scale of 1 to 4 to measure the presence of air bubbles, biliary secretion, and residue.

The researchers reported that the quality of images were not different in Group A compared with Group B in the duodenojejunum and in the ileum.

Gastric transit time tended to be shorter in Group A of 26 minutes compared with Group B of 46 minutes.

The research team also found that small bowel transit was not different between groups A and B, of 271 versus 288 minutes, respectively.

In addition the team observed that total small bowel capsule endoscopy examination was complete in Group A and in 24 of 26 patients in Group B.

Potential bleeding lesions were seen in 8 patients in Group A and 12 in Group B, although these differences were not significant.

Dr Ben-Soussan’s team concluded, “Our retrospective study suggests that 2 L polyethylene glycol preparation seems able to improve neither the quality of capsule endoscopy images nor its diagnostic performance.”

“Moreover, in our study, polyethylene glycol tended to increase gastric emptying time and may constitute a limitation for small bowel complete examination.”

J Clin Gastroenterol 2005: 39(5): 381-384
21 April 2005

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