Obesity is closely associated with the increased morbidity and mortality of many common diseases in the Western world, including coronary heart disease and gallstone diseases.
Dr Méndez-Sánchez and colleagues from Mexico investigated the association between gallstones and coronary heart disease in a cross-sectional study.
The investigative team considered subjects who had gallstones visible by ultrasound as cases and subjects negative for gallstones were classified as controls.
The team defined positive coronary heart disease when the stress test was positive.
|Subjects with gallstones had a 16% prevalence of coronary heart disease compared with 5% in controls|
|American Journal of Gastroenterology|
The investigators measured body mass index, waist circumference, blood pressure, serum lipid concentrations, and insulin resistance were measured.
The researchers estimated the association by odds ratios using logistic regression models adjusted for confounders.
473 subjects (292 males and 181 females) were included, comprising 354 controls and 119 cases.
The research team found that subjects with gallstones had higher prevalence of coronary heart disease of 16% than controls with a 5% prevalence.
After the researchers applied univariate unconditional logistic regression analysis, the most important risk factors for gallstone diseases included coronary heart disease.
The other most important risk factors identified by the team were body mass index of 30 kg/m2, waist circumference, high blood pressure, and homeostasis model assessment of insulin resistance of more than 2.5.
In a multivariate analysis that adjusted for age, gender, and body mass index, the risk for gallstone diseases in subjects with coronary heart disease was higher.
Dr Méndez-Sánchez’s team concluded, “Subjects with coronary heart disease have an increased risk to have gallstone diseases.”
“Both diseases are strongly associated and the main characteristics of these subjects are those frequently involved as part of the metabolic syndrome.”