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 20 January 2018

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News

The association of Helicobacter to body mass index in the USA

The latest issue of Alimentary Pharmacology & Therapeutics finds that Helicobacter pylori and cytotoxin-associated gene product A antibody status is not associated with obesity, overweight, or fasting serum leptin levels in the USA population.

News image

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Helicobacter pylori infection may decrease serum ghrelin and increase gastric leptin levels, which may, in turn, decrease body mass index.

Dr Ioannou and colleagues from Seattle, Washington determined whether H. pylori seropositivity is associated with body mass index.

The researchers measured serum H. pylori and cytotoxin-associated gene product A antibody levels on 6724 adult participants of the third National Health and Nutrition Examination Survey from 1988 to 1991.

H. pylori and cytotoxin-associated gene product A antibody status was not associated with obesity
Alimentary Pharmacology & Therapeutics

The investigators evaluated the association between H. pylori and cytotoxin-associated gene product A antibody status adjusting for sociodemographic factors.

The associations studied by the investigative team included both both negative, H. pylori-positive and cytotoxin-associated gene product A-negative, or both positive and body mass index.

The team also investigated whether H. pylori and cytotoxin-associated gene product A antibody status was associated with fasting serum leptin levels.

The researchers found that H. pylori and cytotoxin-associated gene product A antibody status was not associated with obesity (defined as body mass index 30 kg/m2) or overweight (body mass index 25 to less than 30 kg/m2).

In addition, the researchers noted that H. pylori and cytotoxin-associated gene product A antibody status was not associated with fasting serum leptin level in the USA population.

“Dr Ioannou’s team concluded, “H. pylori seropositivity and antibody status are not associated with body mass index or fasting serum leptin levels.”

Aliment Pharmacol Ther 2005: 21(6): 765
29 March 2005

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