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 19 November 2017

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News

Clinical trial: Cranberry juice can suppress H Pylori infection

April's issue of Helicobacter reports that at day 35 of intervention 14% from the cranberry juice treatment group and 5% of the placebo recipients had negative 13C-urea breath test results and that regular consumption of cranberry juice can suppress H Pylori infection in endemically afflicted populations.

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Helicobacter pylori infection is a major cause of peptic ulcer disease and gastric cancer.

Dr Wei-cheng You and colleagues postulated that cranberry juice would be effective in the suppression of H Pylori in an endemically infected population at high risk for gastric cancer.

The investigative team conducted a prospective, randomized, double-blind, placebo-controlled trial in Linqu County of Shandong Province, China.

The researchers randomly divided 189 adults, with a mean age of 49 years, with H Pylori infection into two groups receiving cranberry juice (n = 97) or placebo (n = 92).

The 13C-urea breath test was used to determine the degree and assess the alleviation of infection
Helicobacter

Participants were assigned by the research team to orally receive 2 x 250-ml juice boxes of cranberry juice or matching placebo beverage daily for 90 days.

The investigators determined the degree of H Pylori infection by using the 13C-urea breath test before randomization at 35 and 90 days of intervention to assess the efficacy of cranberry juice in alleviating infection.

A total of 189 subjects with positive 13C-urea breath test results prior to randomization completed the study.

The researchers reported that at day 35 of intervention, 14 of the 97 (14%) from the cranberry juice treatment group and 5 of the 92 (5%) of the placebo recipients had negative 13C-urea breath test results.

After 90 days, the team concluded that 14 of the 97 subjects in the cranberry juice treatment group versus 5 of the 92 in the placebo group yielded negative test results.

In addition, 11 individuals from the cranberry juice treatment group and only 2 from the placebo group were shown to be significantly negative at 35 and 90 days of the experiment.

Dr Wei-cheng You concludes, “Regular consumption of cranberry juice can suppress H Pylori infection in endemically afflicted populations.”

Helicobacter 2005: 10(2): 139
17 March 2005

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