The role of coffee in the development of hepatocellular carcinoma is debated.
Dr Gelatti and colleagues from Italy investigated the role of coffee in hepatocellular carcinoma, taking the main risk factors into account.
The investigative team conducted a hospital-based case-control study in northern Italy.
250 Hepatocellular carcinoma cases and 500 controls hospitalized for any reasons other than neoplasms, and liver and alcohol-related diseases were recruited by the investigators.
The researchers interviewed subjects on their lifetime history of coffee consumption using a standardized questionnaire.
| Coffee consumption was associated with a decreasing risk of hepatocellular carcinoma with a clear dose-effect relation |
|Journal of Hepatology|
Coffee consumption in the decade before the interview was associated with a decreasing risk of hepatocellular carcinoma with a clear dose-effect relation.
The investigators noted that with respect to non-drinking subjects, the odds ratios were: 0.8 for 1–2 cups/day, 0.4 for 3–4 cups/day and 0.3 for 5 or more cups/day.
The odds ratios for hepatocellular carcinoma decreased for drinking more than 2, compared to 0–2 cups/day of coffee.
The researchers also reported that for an alcohol intake more than 80g/day the odds ratios decreased from 6 to 3, for presence of Hepatitis B virus infection from 16 to 7 or Hepatitis C virus infection from 38 to 9.
Dr Gelatti concluded that, “Coffee drinking was inversely associated with hepatocellular carcinoma regardless of its aetiology.”