Smoking is a recognized risk factor for pancreatic cancer and has been associated with chronic pancreatitis and also with type 2 diabetes.
Dr Maisonneuve and colleagues investigated the effect of tobacco on the age of diagnosis of pancreatitis and progression of disease, as measured by the appearance of calcification and diabetes.
The investigative team used data from a retrospective cohort of 934 patients with chronic alcoholic pancreatitis where information on smoking was available, who were diagnosed and followed in clinical centres in 5 countries.
The team compared age at diagnosis of pancreatitis in smokers versus non-smokers.
|Diagnosis of pancreatitis was made, on average, 5 years earlier in smokers than in non-smokers|
The Cox proportional hazards model was used by the researchers to evaluate the effects of tobacco on the development of calcification and diabetes, after adjustment for age, sex, centre, and alcohol consumption.
The research team noted that diagnosis of pancreatitis was made, on average, 5 years earlier in smokers than in non-smokers.
Tobacco smoking increased significantly the risk of pancreatic calcifications for smokers versus non-smokers and to a lesser extent the risk of diabetes during the course of pancreatitis.
Dr Maisonneuve concluded that, “In this study, tobacco smoking was associated with earlier diagnosis of chronic alcoholic pancreatitis and with the appearance of calcifications and diabetes, independent of alcohol consumption."