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 19 November 2017

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News

Predictors of survival in curative resection for colorectal cancer

The results of a study reported in the most recent issue of British Journal of Cancer show that low tumour CD4+ T-lymphocyte infiltration is associated with elevated C-reactive protein concentrations and that both predict poor cancer-specific survival.

News image

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There is increasing evidence that both local and systemic inflammatory responses play an important role in the progression of a variety of common solid tumours.

Dr McMillan and colleagues from Scotland examined the relationship between tumour T-lymphocyte subset infiltration, the systemic inflammatory response and cancer-specific survival in patients with colorectal cancer.

The research team studied 147 patients undergoing potentially curative resection for colorectal cancer.

Circulating concentrations of C-reactive protein were measured prior to surgery.

C-reactive protein and percentage tumour volume of CD4+ T-lymphocytes were associated with survival
British Journal of Cancer

The researchers also assessed CD4+ and CD8+ T-lymphocyte infiltration of the tumour using immunohistochemistry and a point counting technique.

The team found that when patients were grouped according to the percentage tumour volume of CD4+ T-lymphocytes, there was no difference in terms of age, sex, tumour site, stage and tumour characteristics.

However, the researchers noted an inverse relationship between percentage tumour CD4+ T-lymphocytes and C-reactive protein.

The investigators used univariate analysis, which showed that both C-reactive protein concentrations and percentage tumour volume of CD4+ T-lymphocytes were associated with cancer-specific survival.

Dr McMillan concluded, “The results of the present study show that low tumour CD4+ T-lymphocyte infiltration is associated with elevated C-reactive protein concentrations and both predict poor cancer-specific survival.”

British Journal of Cancer 2005: 92: 651-654
04 March 2005

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