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 20 April 2018

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News

Gender differences in graft survival after pancreas-kidney transplant

A report in the latest Clinical Transplantation shows there is greater early (less than 6 months) pancreas graft failure in women than men but no gender difference in kidney graft failure in the same individuals.

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Gender differences in graft survival have been reported after some types of organ transplantation, but not after pancreas transplantation.

Dr Larsen and colleagues from Nebraska, America compared graft survival between women and men after simultaneous pancreas-kidney transplantation.

The research team performed all first time simultaneous pancreas-kidney transplants (n = 163) where 109 were male and 54 were female between 1989 and 2000 at the University of Nebraska Medical Center.

The team analyzed overall graft and patient survival where data was available.

Early pancreas graft failure was greater in women than men with no one cause for failure predominant
Clinical Transplantation

The researchers then subdivided graft failure into early (less than 6 months), and late (more than 6 months) compared between women and men.

The 5 year pancreas and kidney graft survival rates for all simultaneous pancreas-kidney transplants recipients was 86% and 87% between women and men, respectively.

The investigators noted that while overall pancreas graft survival in women was similar to men, early pancreas graft failure was greater in women than men with no one cause for failure predominant.

In addition, the team observed no gender difference in late pancreas graft failure or in early, or late kidney graft failure in the same recipients.

The researchers also found that the gender difference was unexplained by differences in age, immunosuppression, body mass index, or diabetes duration between women and men.

Dr Larsen concludes, “This is the first report of a gender difference in pancreas graft survival after simultaneous pancreas-kidney transplants with greater early (less than 6 months) pancreas graft failure in women than men.”

“With no gender difference in kidney graft failure in the same individuals, gender differences in immune responses are unlikely to be the cause and multiple variables are likely contribute.”

Clinical Transplantation 2005: 19(2): 158
04 March 2005

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