The impact of pregnancy on Crohn's disease activity has been poorly investigated.
Professor Beaugerie and colleagues from France determined the effect of pregnancy on Crohn's disease activity from the retrospective analysis of a cohort of women who had a regular clinical follow-up.
The investigative team studied 70 pregnancies occurring in 61 women.
|The mean HarveyBradshaw index during pregnancy was lower than that of the year preceding pregnancy|
|Alimentary Pharmacology & Therapeutics|
The team assessed the HarveyBradshaw index during the 4 quarters preceding each pregnancy, the 3 quarters of pregnancy and the 4 quarters following delivery.
The researchers found that the mean HarveyBradshaw index during pregnancy was significantly lower than that of the year preceding pregnancy and that of the year following delivery.
In addition, the research team reported that there was no significant change of HarveyBradshaw index between these intervals in non-smoking women (48 pregnancies).
The researchers noted that in those who smoked (22 pregnancies), most of whom reduced tobacco consumption during pregnancy, the mean HarveyBradshaw index during pregnancy was significantly reduced compared with that of the year following delivery.
The use of drugs was significantly lower during pregnancy.
Professor Beaugerie concludes, “Crohn's disease activity is mildly but significantly lower during pregnancy.”
”The reduction of tobacco consumption during pregnancy in smoking women may play an important role in this improvement.”