Population data that support an association between autoimmune cholestatic liver diseases, primary biliary cirrhosis and primary sclerosing cholangitis and celiac disease, is limited and at times contradictory.
Dr West and colleagues from England aimed to explore the relationship between celiac disease and both primary biliary cirrhosis and primary sclerosing cholangitis.
The researchers used the General Practice Research Database, a UK-based longitudinal primary care database.
The research team identified 4732 people with diagnosed celiac disease.
23 620 Age- and sex-matched controls within the General Practice Research Database were also identified by the researchers.
There is a higher prevalence of primary biliary cirrhosis in adults with celiac disease compared with control groups|
|Alimentary Pharmacology and Therapeutics|
The investigators calculated the prevalence of primary biliary cirrhosis and primary sclerosing cholangitis for both the celiac disease and control group.
The team showed that there was a higher prevalence of primary biliary cirrhosis in adults with celiac disease (0.17%), compared with controls (0.05%).
Primary sclerosing cholangitis was also shown to be more common in the celiac disease group (0.04%) than in the control group (0%).
Dr West concluded that “There was a threefold or greater increase in risk of both primary biliary cirrhosis and primary sclerosing cholangitis in people with celiac disease compared with the general population”.
The research team mentioned that the association with primary biliary cirrhosis was weaker than in some reports.
The investigators concluded that it was difficult to justify screening patients with celiac disease for either primary biliary cirrhosis or primary sclerosing cholangitis.