Family history and appendicectomy are known risk factors for inflammatory bowel diseases, however, changes in risk based on domestic promiscuity, certain vaccinations, and dietary factors provide new etiological clues, reports March's Gut.
Environmental exposures in early life have been implicated in the etiology of inflammatory bowel disease.
Professor Colombel and colleagues from Lille, France undertook a study in order to examine environmental risk factors prior to the development of inflammatory bowel disease in a pediatric population based case control study.
The researchers recorded a total of 222 incident cases of Crohn’s disease and 60 incident cases of ulcerative colitis that occurred before 17 years of age between January 1988 and December 1997.
The research team then matched each case with 1 control subject by sex, age, and geographical location.
The research team recorded 140 study variables in a questionnaire.
The questionnaire covered familial history of IBD, events during the perinatal period, infant and child diet, vaccinations and childhood diseases, household amenities, and the family’s socioeconomic status.
|Breast feeding, BCG vaccination, and history of eczema are significant risk factors for Crohn’s|
Using a multivariate model, the researchers found that familial history of IBD, breast feeding, BCG vaccination, and history of eczema were significant risk factors for Crohn’s disease whereas regular drinking of tap water was a protective factor.
In addition, the team noted that familial history of IBD, disease during pregnancy, and bedroom sharing were risk factors for ulcerative colitis whereas appendicectomy was a protective factor.
Professor Colombel concluded, "While family history and appendicectomy are known risk factors, changes in risk based on domestic promiscuity, certain vaccinations, and dietary factors may provide new etiological clues."