Dr Fossmark, Dr Johnsen, Dr Johanessen and Dr Waldum from Trondheim, Norway undertook a study in order to estimate the duration of hypersecretion and to elucidate the role of the enterochromaffin-like (ECL) cell in rebound acid hypersecretion.
The research team included patients waiting for anti-reflux surgery who had used a proton pump inhibitor daily > 1 year.
All patients discontinued taking acid inhibiting drugs after the operation.
The research team measured basal and pentagastrin stimulated acid output at 4, 8, 16 and 26 weeks postoperatively.
In addition, the researchers collected oxyntic mucosal biopsies before and 26 weeks after the operation for counting of histidine decarboxylase (HDC) immunoreactive cells.
The research team measured serum chromogranin A (CgA) and gastrin before and at 4, 8, 16 and 26 weeks after the operation.
|Rebound acid hypersecretion lasts more than 8 weeks, but less than 26 weeks after long-term proton pump inhibition|
|Alimentary Pharmacology and Therapeutics|
The researchers found that pentagastrin stimulated acid secretion was higher at 4 and 8 weeks than at 26 weeks after the operation.
In addition, the team noted that gastrin and CgA were significantly reduced at 4 and 8 weeks, respectively.
The number of HDC immunoreactive cells was reduced by 60% at 26 weeks postoperative.
The researchers observed that rebound acid hypersecretion lasts more than 8 weeks, but less than 26 weeks after long-term proton pump inhibition.
Dr Fossmark concluded, "The findings indicate that not only the parietal cell mass, but also enterochromaffin-like cell mass and activity are involved in the mechanism of acid hypersecretion."