Establishing predictors of quality of life (QoL) in individuals with inflammatory bowel disease could help to identify those patients who are most likely to experience poor quality of life.
It would then be possible to target therapeutic interventions appropriately.
Dr Welfare and colleagues undertook a study to investigate how disease-specific QoL depends on demographic, disease related, and physiological markers of disease activity, cognitive representations of illness, and perceived general health status.
The researchers collected a total of 111 Inflammatory Bowel Disease Questionnaires (IBDQ), Medical Outcomes Study 36-Item Short-Form Health Surveys (SF-36), and Illness Perception Questionnaires (IPQ).
The research team was able to determine the extent of disease from records, and disease activity by a symptom index.
The researchers used bivariate analyses and multivariate regression models to identify predictors of disease-specific quality of life.
|Disease activity was the major explanatory variable for the total score on the IBDQ|
|Inflammatory Bowel Diseases|
The researchers examined symptom-related disease activity, elements of illness representation measured by the IPQ, and elements of physical and mental health measured by the SF-36.
The research team found that these were the only variables that were strongly or moderately correlated with disease-specific QoL.
The investigators also showed using multivariate regression modeling that disease activity was the major explanatory variable for each of the 4 domains and for the total score on the IBDQ.
Dr Welfare concluded, "This study highlights the strong relationship between individuals' symptoms and all domains of their health-related QoL."
"However, it shows little association between symptoms and age, gender, physiological markers of disease activity, or anatomic disease extent."
"Perceptions of the condition were relatively weak predictors of self-reported QoL."