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 24 January 2018

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News

Children with early-onset inflammatory bowel disease

Research in January's Journal of Pediatrics reveals an age-related variation in the distribution of inflammatory bowel disease phenotype, with a high prevalence of isolated colonic disease in young children.

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Dr Heyman and colleagues from America designed a study in order to determine the characteristics of inflammatory bowel disease (IBD) in young patients.

The researchers collected uniform data from a cohort of patients with IBD who were enrolled from January 2000 to November 2002 at six pediatric centers (Pediatric IBD Consortium).

The researchers noted that out of a total of 1370 children in the registry, the mean age at IBD diagnosis was 10.3 ± 4.4 years; 54% were male, and 86% were white.

Diagnosis was confirmed in 6% under 3 years of age, 15% before 6 years, 48% at 6 to 12 years, and 37% at 13 to 17 years.

Only 35% of those 8 years of age or older had isolated colonic disease
Journal of Pediatrics

The researchers found that more than 63% of children younger than 8 years of age had isolated colonic disease, whether Crohn's disease, ulcerative colitis (UC), or indeterminate colitis.

Conversely, the research team noted that only 35% of those 8 years of age or older had isolated colonic disease.

Overall, 29% had one or more family members with IBD.

The subgroup of children younger than 3 years of age with ulcerative colitis had the highest prevalence of first-degree relatives with IBD (44%).

Dr Heyman concluded, "This demographically diverse pediatric IBD cohort revealed age-related variation in the distribution of IBD phenotype, with a high prevalence of isolated colonic disease in young children."

"Positive family history was especially common in young patients with ulcerative colitis."

Journal of Pediatrics; 2005: 146 (1)
14 January 2005

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