Seronegative hepatitis is a common cause of acute liver failure (ALF) requiring liver transplantation.
Dr Wigg and colleagues from South Australia undertook a study in order to examine outcomes following transplantation in this group and to identify factors associated with early (<2 months) mortality.
The researchers studied 110 consecutive cases of seronegative ALF transplanted at the Queen Elizabeth Hospital, Birmingham, between January 1992 and January 2004.
The research team preformed univariate analysis of 44 pretransplantation recipient, donor, and operative variables in order to identify factors associated with early posttransplantation mortality.
|Survival following transplantation for seronegative hepatitis was 83%, 81%, and 73% at 2, 12, and 60 months, respectively|
The researchers used multiple logistic regression analysis in order to identify variables as significant or approaching significance.
The research team found that survival following transplantation for seronegative hepatitis was 83%, 81%, and 73% at 2, 12, and 60 months, respectively.
In addition, the researchers noted that the majority (71%) of deaths occurred within the 1st 2 months and sepsis / multiorgan dysfunction was the most common cause of early death.
Univariate analysis revealed 9 variables predicting early death.
On subsequent multivariate analysis, the investigators identified high donor body mass index (BMI; a possible surrogate marker for hepatic steatosis) as the most important predictor of early death.
The researchers noted that recipient age >50 and non-Caucasian recipient ethnicity were other variables associated with early death.
This study specifically examined factors that determine the early outcome of transplanted seronegative ALF patients.
Dr Wigg concluded, "We found that donor and recipient factors identify patients who have a high chance of early death after transplantation."