Numerous studies have reported on the association between celiac disease and the otherwise uncommon enteropathy-type T cell lymphoma (ETTL).
A systematic risk assessment of more prevalent lymphoma entities, such as B cell and non-intestinal lymphomas, in celiac disease has not yet been performed.
Increasing numbers of patients are diagnosed with celiac disease and the etiology of malignant lymphomas is as yet unknown.
In light of this, a group of researchers from Stockholm, Sweden lead by Dr Smedby undertook a study in order to estimate the distribution and risk of lymphoma subtypes in celiac disease.
|57% of lymphomas in the cohort were not intestinal T cell lymphomas|
The researchers reviewed and reclassified 56 cases of incident malignant lymphomas occurring in a Swedish population based cohort of 11 650 patients hospitalized with celiac disease.
The researchers then compared the observed numbers of lymphoma subtypes with those expected in the Swedish population.
The majority (57%) of lymphomas in the cohort were not intestinal T cell lymphomas.
The researchers found that there were significantly increased risks for B cell non-Hodgkin lymphoma (NHL); 11 non-intestinal and five intestinal and for lymphomas of non-intestinal origin.
Furthermore, the researchers noted that 44% of patients with B cell non-Hodgkin lymphoma had a history of other autoimmune/inflammatory diseases.
The research team noted that the relative risks for T cell NHL and for primary gastrointestinal lymphomas were markedly increased, as anticipated.
Dr Smedby concluded, "Most lymphomas complicating celiac disease are indeed related to the disease and are not of the ETTL-type."
"There was a remarkable aggregation of autoimmune/inflammatory disorders, female sex, celiac disease, and B cell lymphoma."