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 22 January 2018

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News

Colorectal cancer gene clues from analysis of completed Human Genome Project

Scientists have found new clues to the genetic causes of colorectal cancer following the completion of the human genome project, now published in Nature and Science.

News image

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The genome has revealed an unexpected pattern of active genes, and this has enabled scientists to step up the search for cancer-related genes, according to one of the reports in Science.

The combination of patterns of RIDGE (regions of increased gene expression) and the smaller than expected number of humans genes has led to optimism that pharmaceutical applications can be developed rapidly, scientists said.

In their Science report a team, led by Huib Caron, from the University of Amsterdam, the Netherlands, say they have turned up several genes that are either ‘silenced' or over-expressed in colon cancers and in breast cancer and neuroblastoma.

By using RIDGE analysis they were able to identify differences between genes in healthy tissue and in cancerous tissue.

Genes found that are either silenced or over-expressed in colon cancer.
Science
Meanwhile in Nature, Dr Gerald Rubin, of Berkeley University, California, USA, and fellow researchers report on the development of the faulty APC gene that can cause colorectal cancer.

Their analysis shows that many of the human genes that are not found in flies, worms, and other animals have been assembled out of ‘old parts' and built up from strands of parasitic DNA, known as transposons.

Such a transposition in the APC gene leads to cancer, they say.

Philip Campbell, editor in chief of Nature, said, "Our bodies, our behavior, and our minds couldn't exist without the human genome, and are all profoundly influenced by its content in ways that we have yet to fathom. The sequence unveiled today by the International Human Genome Sequencing Consortium unlocks new ways of exploring those influences."

Report Copyright: Englemed Health News at http://www.internationalmedicalnews.com

Nature 2001
12 February 2001

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