There is a high prevalence of osteopenia among patients with Crohn's disease (CD).
There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss.
Dr Cashman and colleagues from Ireland designed a study in order to compare the intake and the status of vitamin K in Crohn's disease patients, currently in remission, with age- and sex-matched controls.
The research team also investigated the relationship between vitamin K status and bone turnover in these patients.
The researchers recruited 44 Crohn's disease patients and matched controls (n = 44) from the Cork University Hospital and Cork City area, respectively.
The research group analyzed blood samples for the total and undercarboxylated (Glu)-osteocalcin.
| Glu and NTx concentrations in Crohn's disease patients are higher than in controls|
|American Journal of Gastroenterology|
In addition, the team tested urine for cross-linked N-telopeptides of type I collagen (NTx).
The researchers estimated vitamin K1 intake by food frequency questionnaire.
The research team found that vitamin K1 intake in Crohn's disease patients tended to be lower than that of controls.
In addition, they found that Glu and NTx concentrations in Crohn's disease patients were higher than controls.
In Crohn's disease patients, Glu was significantly correlated with NTx, even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use.
Dr Cashman concluded, "Vitamin K status of Crohn's disease patients was lower than that of the healthy controls."
"Furthermore, the rate of bone resorption in the Crohn's disease was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for Crohn's disease-related osteopenia."