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News

NSAIDs increase disease activity score among Crohn's disease patients

NSAIDs are associated with a higher numerical disease activity index score among Crohn's disease patients with colonic involvement, but not an increase in significant disease flares, reports November's Inflammatory Bowel Diseases

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Dr Sridhar and colleagues carried a study to examine whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in outpatients with inflammatory bowel disease was associated with increased severity of disease activity.

The doctors saw 426 outpatients with Crohn's disease and a total of 203 patients with ulcerative colitis between November 1997 and April 2002.

The researchers questioned the patients at each visit regarding the use of prescription or over-the counter NSAIDs.

Using this information, the researchers were able to obtain a clinical disease activity index.

The researchers found that the Crohn's patients used no NSAIDs on 1315 visits, low dose NSAIDs on 215 visits and for 139 visits high-dose NSAIDs were taken.

For the UC patient visits, 495 used no NSAIDs, 112 low-dose NSAIDs, and 49 high-dose NSAIDs.

Probability of moderately active disease was not significantly affected by NSAID use
Inflammatory Bowel Diseases

The researchers calculated that the average MHB score was 4.07 for the no-NSAID group, 4.24 for low-dose NSAIDs, and 4.78 for high-dose.

For the ulcerative colitis patients corresponding scores were 5.64, 5.46, and 6.20, respectively.

The research group found that the probability of moderately active disease however, was not significantly affected by NSAID use.

The investigators analyzed each subgroup and found that the increase in disease activity among CD patients taking high-dose NSAIDs was limited to patients with colonic involvement.

Use of low-dose NSAIDs was not associated with an increase in disease activity for these outpatients with either CD or UC.

Dr Sridhar concluded, "Use of high-doses of NSAIDs was associated with a higher numerical disease activity index score among CD patients with colonic involvement, but this was not reflected by an increase in significant disease flares."

Inflammatory Bowel Diseases; 2004: 10(6):751-757
26 October 2004

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