Investigators from Athens, Greece undertook a prospective, randomized and controlled study to determine the value of small-bowel preparation for patients undergoing capsule endoscopy.
The researchers referred a total of 80 patients for capsule endoscopy and then randomly allocated them into two groups.
The investigators gave patients in Group A (mean age 54.40 years) 2 L of a polyethylene glycol/electrolyte solution to ingest 16 hours before the test.
The researchers gave patients in Group B (mean age 59.85 years) only clear liquids during the prior day in preparation for the procedure.
|65% of patients given bowel preparation had an established diagnosis, compared to 30% of patients who had had no bowel preparation|
The research team evaluated the effect of bowel preparation on the quality of capsule images, as assessed with an objective scoring system in which cleansing was graded as "adequate" or "inadequate" by blinded examiners.
The investigators looked at the effect of bowel preparation on diagnostic yield as a secondary outcome.
For this purpose, the researchers classified the results of capsule endoscopy as positive findings, findings of uncertain significance, and no findings.
The investigators considered that cleansing of the small intestine was "adequate" in 36 patients in Group A (90%) vs. 24 patients of Group B (60%).
The researchers noted that a diagnosis was established in 26 patients in Group A (65%) compared with 12 patients in Group B (30%).
Dr Avgerinos, on behalf of the group, concluded, "Bowel preparation before capsule endoscopy improves visualization of the small intestine, which may lead to an improvement in diagnostic yield."