Professor Nissar Darmani, of the Kirksville College of Osteopathic Medicine, Missouri, USA, reports that the CB1 receptor for marijuana is the anti-vomiting receptor.
The discovery has come from research on the shrew, the smallest animal in which vomiting is known to happen.
During the research, he tested antagonists for two cannabinoid receptors, CB1 and CB2, on the animals.
|Marijuana prevents vomiting via the CB1 receptor.|
The research showed that SR 141716A (the CB1 antagonist) induced vomiting, while SR 144528 (the CB2 antagonist) did not.
Professor Darmani said he hoped his research would lead to new anti-emetic drugs to help alleviate the side-effects of cancer chemotherapy.
"We hope to find marijuana-like drugs that do not give the high, but can prevent vomiting," he concluded.
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