Researchers from Indiana, America looked at the relationship between distal diverticulosis and risk for colorectal neoplasia in patients undergoing first-time colonoscopy.
The researchers deemed patients eligible if they had no prior polypectomy, colonic resection, or inflammatory bowel disease.
The researchers gave patients a survery to complete about risk factors for colorectal cancer (CRC) prior to colonoscopy.
Endoscopists who were blinded to study objective and survey results, recorded the size, extent (none, few, or many), and location of diverticuli and polyps.
In total, 67% of the 502 participants were male with a mean age of 58.6 yr.
23% were found to have extensive distal diverticulosis (EDD), 36% had 1 adenoma, and 14% had advanced neoplasia.
|Distal neoplasia in women with distal diverticulosis accounted for their increased risk of proximal neoplasia|
|American Journal of Gastroenterology|
The research group looked at the overall comparison of those with EDD versus few or no diverticuli and found that there were no differences in the risks of any neoplasia or advanced neoplasia, either distally (26.7%vs 25.4%; 12.9%vs 8.8%, respectively) or proximally (25%vs 18.4%; 6.0%vs 4.9%).
Compared to women with few or no distal diverticuli, however, women with EDD were more likely to have any neoplasia and advanced neoplasia, both distally (34.6%vs 16.3%, and 23.1%vs 5.7%;) and proximally (30.8%vs 14.9%, and 11.5%vs 4.3%).
The researchers made adjustments for age, but this did not affect results for advanced distal neoplasia.
However, after adjustment for the presence of a distal neoplasm, the researchers found that the increased risk of proximal neoplasia associated with EDD was eliminated.
The group concluded that in this study, women with EDD were more likely to have advanced distal neoplasia.
Dr Ben Kieff commented, "The presence of distal neoplasia in women with EDD accounted for their increased risk of proximal neoplasia."
He added, "Distal diverticulosis was not independently associated with proximal neoplasia in men or women."