Researchers in Poland carried out a study to evaluate the efficacy of a gentamycin collagen sponge placed in the pelvic cavity after excision of rectal cancer.
The group were interested in analysing postoperative complications and the risk of cancer recurrence.
The researchers recruited 229 patients in total who were then randomly assigned to 2 groups: GRM (+) in which the gentamycin sponge was used, and GRM (-) without the sponge.
Tumors were resected using a TME technique.
|Gentamycin sponge lowers the rate of distant metastasis|
In the GRM (+) group, the sponge was placed in the tumour bed.
The researchers were able to analyse 218 patients for whom all follow-up data were available.
They found that there were fewer early postoperative complications in the GRM(+) group: 20.7 vs 37.5%.
The group reported that this effect was mainly in patients that had undergone surgery lasting longer than 3 hours.
A follow-up after 36 months revealed that the overall survival after rectal cancer resection for the GRM (+) and GRM (-) groups was: 88.6 vs. 73.96%.
The researchers findings also indicated that there was a significant reduction in the distant metastasis rate in favour of the GRM (+) group.
Dr Nowacki reported, "The use of the gentamycin collagen sponge after excision of rectal cancer is safe and reduces the rate of early postoperative complications."
The group commented that "The reasons for the lower rate of distant metastasis in the GRM (+) group are not clear, however it was clear that the patients enjoy significant survival benefits".