There are several non-hypercalcemic analogs of 1,25-dihydroxyvitamin D3 which show anti-tumor activity in some cancer patients.
High vitamin D receptor expression is associated with good prognosis but is lost during tumor progression.
|High vitamin D receptor expression is associated with good prognosis.|
In this study, researchers from Spain found that the SNAIL transcription factor represses vitamin D receptor gene expression in human colon cancer cells.
They also determined that the SNAIL transcription factor blocks the anti-tumor action of the 1,25-dihydroxyvitamin D3 analog, EB1089, in xenografted mice.
Dr Héctor Pálmer and colleagues concluded, "In human colon cancers, elevated SNAIL expression correlates with downregulation of vitamin D receptor".