Patients with cirrhosis often undergo radiological procedures that require the administration of contrast media.
Contrast media can cause renal failure.
It is not known if cirrhosis is a risk factor for contrast media-induced renal failure.
In this study, researchers from Spain assessed the possible nephrotoxicity of contrast media in patients with cirrhosis.
The team evaluated renal function before and 48 hours after the administration of contrast media in 31 patients with cirrhosis.
They also measured solute-free water clearance, urine sodium, prostaglandins, and markers of tubular damage.
The team determined that the administration of contrast media was not associated with significant changes in renal function tests.
They found that urinary prostaglandin E2 and N-acetyl--D-glucosaminidase increased significantly, but sodium and solute-free water excretion remained unchanged.
The team also prospectively examined a second series of 60 patients with cirrhosis and renal failure. In this series, no patient had renal failure due to contrast media.
They found that 1 patient with septic shock contrast media a possible contributing factor.
Dr Mònica Guevara and colleagues concluded, "The administration of contrast media is not associated with adverse effects on renal function in patients with cirrhosis".
"Cirrhosis does not appear to be a risk factor for the development of contrast media-induced nephrotoxicity."