Factors influencing the long-term histological outcome of liver grafts are not known.
In this study, investigators from France assessed 10-year liver biopsies to identify the main factors influencing long-term graft histology.
They evaluated 270 of 423 patients who still had their first functional graft 10 years after liver transplantation.
All biopsy slides were reviewed by 2 pathologists.
The investigators found fibrosis in 54% of patients and ductopenia in 29%.
They determined that ductopenia was independently related to higher donor age.
| Ductopenia was independently related to higher donor age.|
|Journal of Hepatology|
The severity of fibrosis was influenced by hepatitis C virus (HCV) infection, hepatitis B virus (HBV) recurrence, and higher donor age.
The team found that 30% of biopsies showed minimal-change lesions which were associated with the absence of HCV or HBV infection, and lower donor age.
Dr Kinan Rifaia and colleagues concluded, "Post-transplant infection by HCV or HBV are main factors influencing the histological course of liver graft".
"Donor age was also a strong factor in HCV infected patients as well as in HCV-negative patients".
"This variable should be taken into account, particularly for candidate recipients with long life expectancy".