Inflammatory bowel disease is uncommon in Southeast Asia but is increasing in incidence.
The epidemiology and phenotype of Crohn's disease in the Chinese population is not well-known.
In this study, physicians assessed the incidence, temporal trend, clinical features, risk factors, extraintestinal manifestations, and treatment in the Chinese population of Hong Kong.
The team recruited 80 Crohn's disease patients.
|Crohn's disease has increase 3-fold in the past decade.|
|Inflammatory Bowel Diseases|
Patients were characterized by male gender predominance, no association with ever smoking, absence of familial clustering, high proportion of upper GI tract disease proximal to the terminal ileum, and a low proportion of isolated terminal ileal disease.
Patients' mean age at diagnosis was 33 years.
The physicians found that 45% of patients had penetrating disease, 18% stricturing disease, and 37% had nonstricturing, nonpenetrating disease.
In addition, 25% of patients had at least 1 extraintestinal manifestation, and there was a high rate of ankylosing spondylitis.
The team determined that the incidence of Crohn's disease was 1 per 100,000; it has increased 3-fold during the past decade.
Dr Rupert Leong and colleagues concluded, "The incidence of Crohn's disease in the Chinese is increasing".
"There are some notable epidemiological and phenotypic differences between Chinese Crohn's disease with Caucasian Crohn's disease including the lack of familial clustering, male predominance, and higher proportion of upper GIT involvement and lower frequency of isolated terminal ileal disease."