In this study, physicians assessed the effect of postoperative immunosuppressive drugs on long-term surgical recurrence rate after second anastomotic ileocolonic resection in patients with Crohn's disease.
The team assessed 26 patients with Crohn's disease who underwent a second resection for ileocolonic anastomotic recurrence between 1984 and 2000.
The team compared 2 groups of patients according to their postoperative treatment.
The first group included 14 patients who were given immunosuppressive drugs, while the second group included patients receiving either salicylates or no treatment.
|Clinical recurrence at 3 years was lower in the immunosuppressive group.|
|Inflammatory Bowel Diseases|
The team found that clinical recurrence at 3 years was significantly lower in the immunosuppressive group than in the control group.
The mean delay of recurrence was similar in both groups.
The physicians also found that a third intestinal resection was performed less frequently in the immunosuppressive group than in control group.
Dr Arnaud Alves and colleagues concluded, "In patients treated with immunosuppressive drugs, the rate of postoperative recurrence after second ileocolonic Crohn's disease resection is lower than in untreated patients".
"Our results suggest that immunosuppresive drugs should be evaluated prospectively for prevention of second postoperative Crohn's disease recurrence."