The impact of primary biliary cirrhosis (PBC) on health-related quality of life is poorly documented.
In this study, investigators from France assessed health-related quality of life in a group of 276 patients (86% women, median age 62 years) with PBC.
The team used the Nottingham Health Profile, a generic scale that assesses 6 major areas commonly associated with health-related quality of life.
The team then compared the data were compared with those of a sex- and age-matched control group.
|Patients with PBC had a significant difference in energy compared to controls.|
They also evaluated the associations between Nottingham Health profile scores and the severity of PBC.
The team determined that the majority of patients were treated with UDCA.
The investigators found that patients with PBC had a significant difference in energy compared to controls (40.6 versus 22.9). They also had poorer scores for emotional reactions (22.2 versus 16.1).
The team did not find any associations of the dimension subscores with biochemical liver tests, histological stages, or duration of the disease.
Dr Renée Eugénie Poupon and colleagues concluded, "Patients with PBC feel that their overall quality of life is worse than that of the control population".
"This difference is mainly due to the decrease in the subscores of energy and emotional reactions, both associated with fatigue".
"These effects must be taken into account by clinicians when treating these patients, as they constitute the clinical outcomes that have the most impact on patients' lifestyle and adherence to treatment".