Some patients may require may require greater acid suppression than that provided by once-daily esomeprazole.
In this study, investigators from the United States assessed gastric acid suppression and pharmacokinetics of twice-daily versus once-daily esomeprazole.
The team performed a randomized, double-blind, 3-way crossover study.
|Esomeprazole 40 mg twice daily provided a mean of 19.2 hours with intragastric pH >4.|
|Alimentary Pharmacology and Therapeutics|
Healthy subjects were given either esomeprazole 40 mg once daily, 20 mg twice daily, or 40 mg twice daily for 5 consecutive days.
The team recorded 24-hour continuous ambulatory intragastric pH.
The investigators found that esomeprazole 40 mg twice daily provided a mean of 19.2 hours with intragastric pH >4. This compared with 14.2 hours for 40 mg once daily and 17.5 hours for 20 mg twice daily.
Dr Katz and colleagues concluded, "Esomeprazole 40 mg twice daily provides significantly greater acid suppression…than once-daily dosing and may be a reasonable consideration for patients requiring greater acid suppression for acid-related disease".