Several indices evaluate disease activity in ulcerative colitis. However, several are invasive or lack specificity.
Fecal excretion of human DNA may be an index of mucosal inflammation and damage.
In this study, researchers from Spain determined whether excretion of human DNA is useful in the evaluation of disease activity in ulcerative colitis.
The team evaluated 36 patients with ulcerative colitis and 31 controls.
Both the patients and controls underwent colonoscopic examination after preparation by gut lavage with polyethylene-glycol electrolyte solution.
|Fecal DNA excretion correlated with disease activity.|
|Clinical Gastroenterology and Hepatology|
Each patient's disease activity was established, and feces and gut lavage fluid were obtained.
The team measured DNA levels using quantitative PCR.
The researchers found that fecal DNA excretion correlated with patient's disease activity.
They determined that fecal DNA excretion was significantly higher in patients with endoscopically or clinically active disease than in controls or patients in remission.
Dr Francesc Casellas and colleagues concluded, "Excretion of human DNA in feces…is a novel noninvasive technique to objectively assess disease activity in ulcerative colitis".