Gastric extranodal marginal zone B cell lymphoma of the mucosa associated lymphoid tissue (MALT)-type (MZBL) is a rare complication of Helicobacter pylori infection.
In this study, investigators from Europe identified the H. pylori genes associated with lymphoma development.
The team used subtractive hybridization to compare genomics between H. pylori strains isolated from 1 patient with gastric MZBL and 1 patient with gastritis only.
They found that 2 open reading frames (ORFs) were significantly associated with gastric MZBL. These were JHP950 and JHP1462.
The investigators established that the prevalence of JHP950 was 49% in duodenal ulcer strains and 39% in gastric adenocarcinoma strains; making this a specific marker for gastric MZBL strains.
The prevalence of JHP1462 was 16% and 36% in duodenal ulcer and adenocarcinoma strains, respectively.
Dr Lehours’s team concluded, “Despite its low prevalence, the ORF JHP1462 can be considered a candidate marker for H. pylori strains involved in severe gastroduodenal diseases.”
“In contrast, the ORF JHP950 has a high prevalence, and is the first candidate marker for strains giving rise to an increased risk of gastric MZBL strains.”
“Further confirmation in other studies is needed.”