The team assessed whether clinical, biological, and histologic parameters in quiescent ulcerative colitis predict time to clinical relapse.
74 patients with clinically- and endoscopically-determined inactive ulcerative colitis were followed up for 1 year, or for a shorter period if they had a relapse.
Serum erythrocyte sedimentation rate; C-reactive protein, interleukin (IL)-1b, IL-6, and IL-15 values; anti-neutrophil cytoplasmic antibody titers; and rectal biopsy specimens were obtained at baseline, at 6 and 12 months, and/or at relapse.
The researchers performed multivariate survival analysis to determine independent predictors of clinical relapse and reported their findings in January's Gastroenterology.
|Shorter times to relapse:|
- 20 to 30-year-old age group
- Women with >5 prior relapses
- Plasmacytosis on rectal biopsy
27 patients relapsed. Multivariate Cox regression analysis retained: (1)younger, (2) greater number of prior relapses, in women, and (3) basal plasmacytosis on rectal biopsy specimens, as predictors of shorter time to clinical relapse.
Kaplan-Meier survival curves showed the 20 to 30-year-old age group and women with more than 5 prior relapses to be groups with shorter times to relapse.
Dr Alain Bitton said on behalf of the group, "Younger age, multiple previous relapses (for women), and basal plasmacytosis on rectal biopsy specimens were independent predictors of earlier relapse."
"These findings may help identify patients with inactive ulcerative colitis who will require optimal maintenance medical therapy," he concluded.