In this study, doctors from Italy tested the possibility of detecting tissue transglutaminase autoantibodies (tTG-Abs) in saliva using a novel sensitive fluid-phase radioimmunoassay (RIA).
The team evaluated paired saliva and serum samples for tTG-Ab prescence.
They analyzed samples from 39 patients with celiac disease (CD) at first biopsy (group 1), 32 controls with a normal duodenal mucosa (group 2), and 32 healthy volunteers (group 3).
The team detected salivary tTG-Abs in 97% of the patients with CD and in 100% of the corresponding serum samples.
They found that all participants in group 3 were negative with both saliva and serum assays.
|There was a correlation between saliva and serum tissue transglutaminase autoantibodies titers.|
|Journal of Pediatrics|
The team identified a correlation between saliva and serum tTG-Ab titers (r=0.826).
Dr Margherita Bonamico's team concluded, "This study demonstrates that it is possible to detect salivary tTG-Abs in CD with a non-invasive, simple to perform, reproducible and sensitive method".