The team assessed the risk and case fatality rate of pyogenic liver abscess in Danish patients with liver cirrhosis compared with the background population.Their findings have been reported in the February issue of Gut.
The researchers identified all patients with liver cirrhosis and pyogenic liver abscess over a 17-year period in the National Registry of Patients. Information on death was obtained from the Danish Central Person Registry.
|Liver abscess risk was increased 15-fold in cirrhosis patients compared with background population.|
22,764 patients with liver cirrhosis and 665 patients with pyogenic liver abscess, of whom 21 were cirrhotics and 644 were non-cirrhotics, were identified.
The crude incidence rate of liver abscess in cirrhotics was found to be 23.3 per 100,000 person years. The age-adjusted risk of liver abscess was increased 15-fold in patients with cirrhosis compared with the background population.
The 30-day case fatality rates in patients with liver abscess and cirrhosis were 38.5 per cent in alcoholic cirrhosis and 62.5 per cent in non-alcoholic cirrhosis, compared with 26.9 per cent in liver abscess patients from the background population. After adjustment for sex, age, and comorbidity, the relative risk of death was found to increase more than 4-fold in alcoholic cirrhosis and non-alcoholic cirrhosis compared with the background population.
Researcher Dr I Mølle, from the Aarhus University Hospital and Aalborg Hospital, Aarhus, Denmark, concluded that, "Liver cirrhosis is a strong risk factor for pyogenic liver abscess associated with a poor prognosis."