A strong genetic influence exists in Crohn's disease (CD). Therefore, a family history of inflammatory bowel disease may be useful for patient classification in patients with Crohn's disease.
In this study, doctors from New York reviewed the medical records of 552 patients with Crohn's disease.
The team classified patients according to the guidelines of the Vienna Classification.
Patients were then divided based on family history of inflammatory bowel disease, and the familial and sporadic groups were compared.
|79% of patients were diagnosed before age 40 years.|
|Inflammatory Bowel Diseases|
The doctors found that overall, 79% of patients were diagnosed before age 40 years.
They established that 26% of patients had disease involving the terminal ileum only (L1), 39% the colon only (L2), 22% the terminal ileum and colon (L3), and 12% the upper gastrointestinal tract (L4).
The team also found that disease behavior was nonstricturing, nonpenetrating (B1) in 28%, stricturing (B2) in 9%, and penetrating (B3) in 63% of patients.
In the familial CD group there were 53 patients with first-degree relatives only, and 96 patients with either first-, second-, or third-degree relatives. The remaining 439 patients had sporadic disease
The team found no differences in sex, age at diagnosis, or disease location.
However, the team identified a difference in disease behavior between the familial and sporadic groups. This difference did not exist when nonstricturing, nonpenetrating cases were excluded from the analysis.
There was no difference between the first-degree relatives only group and the sporadic group.
Dr Spencer Dorn and colleagues concluded, "Using the Vienna Classification, familial and sporadic Crohn's disease differed only in disease behavior".
"However, this difference failed to exist after patients with nonstricturing, nonpenetrating disease were excluded".
"Therefore, familial and sporadic groups appear to be quite similar clinically, and family history does not appear to be a variable useful for disease subclassification".