In this study, doctors from the United States compared the esophageal and gastric cardia carcinoma incidence rates among multiple ethnicities.
The team evaluated the Surveillance, Epidemiology, and End Results (SEER) cancer registry data from 1992 to 1998. They looked at 5 ethnic groups: non-Hispanic whites (Caucasians), white Hispanics (Hispanics), blacks, Asians/Pacific Islanders (Asians/PI), and Native Americans (NA).
The doctors found that the rate of esophageal adenocarcinoma for Caucasian men was 4.2 per 100,000 population per year. This was double the rate for Hispanics and 4-fold higher than for blacks, Asians/PI, and NA (p< 0.01).
|Incidence rates of esophageal adenocarcinoma increased significantly in Caucasians.|
|American Journal of Gastroenterology|
The team observed that the rates for women were much lower than for men for all ethnicities.
Furthermore, the team found that cardia adenocarcinoma rates were also highest in Caucasian males (3.4 per 100,000 population per year). However, for cardia adenocarcinoma, ethnic differences were much less and female rates were comparable for all almost all ethnicities.
The doctors determined that incidence rates of esophageal adenocarcinoma increased significantly in Caucasians during the study period.
The team also found that esophageal squamous cell carcinoma incidence rates were highest in blacks (8.8 per 100,000 population per year) and Asians/PI (3.9 per 100,000 population per year). Rates for all other ethnicities were stable or declined during the study period.
Drs Ai Kubo and Douglas Corley concluded, "Esophageal and cardia carcinoma incidence rates vary much more markedly by ethnicity and gender than previously reported and the two sites differ from each other".
"Current putative risk factors do not adequately explain these large differences".
"These data have implications for risk factor, screening, and intervention studies".