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 23 February 2018

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News

Risk of chronic liver disease and death in patients with fatty liver

Patients with type 1 non-alcoholic fatty liver disease have a benign clinical course without excess mortality, find physicians in the May issue of Gut.

News image

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Fatty liver is a common histological finding in biopsy specimens.

It affects 10 to 24% of the population and is believed to be a marker of risk of later chronic liver disease.

In this study, physicians from Denmark examined the risks of developing cirrhotic liver disease and of death in a cohort with pure fatty liver without inflammation.

The team included 215 patients who had a liver biopsy performed between 1976 and 1987. The cohort included 109 non-alcoholic and 106 alcoholic fatty liver patients.

The participants were followed for a median of 16.7 in the non-alcoholic and 9.2 years in the alcoholic group.

The team reviewed the patients medical records.
Survival estimates were significantly different between the 2 groups.
Gut

The physicians found that in the non-alcoholic fatty liver group, 1 patient developed cirrhosis during the follow up period, compared with 22 patients in the alcoholic group.

The team established that survival estimates were significantly different between the 2 groups; there was a higher death rate in the alcoholic fatty liver group.

The team found that survival estimates in the non-alcoholic fatty liver group were no different from the Danish population.

Dr Dam-Larsen's team concluded, "Patients with type 1 non-alcoholic fatty liver disease have a benign clinical course without excess mortality".

Gut 2004; 53: 750-5
19 April 2004

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