In this study, physicians from Mexico and Spain determined the incidence and variables associated with post-liver transplantation (LT) de novo internal neoplasms development. They excluded skin tumors and hepatocellular carcinoma.
The team reviewed medical records for recipient/donor demographics, viral serology, cause of liver disease, interval from LT to tumor diagnosis, predisposing factors, immunosuppression and survival.
They found that 41 neoplasms developed in 772 recipients (5%) transplanted between 1991 and 2001.
|Hematologic neoplasms appeared earlier than solid neoplasms.|
|American Journal of Transplantation|
The time to tumor diagnosis was longer in patients transplanted before 1995 than in those transplanted afterwards (58 versus 22 months).
The physicians found that hematologic neoplasms (HN) appeared earlier than solid neoplasms (2 versus 21 months). HN were more prevalent in patients transplanted after 1995, they were associated with lower survival than solid neoplasms.
The team determined that HCV was the most frequent indication in HN (70%), and alcohol was the most frequent indication in solid tumors (71%).
Overall, risk factors for de novo neoplasms included alcohol and immunosuppression.
Dr Salvador Benllocha's team concluded, "In patients undergoing LT in recent years, there is a higher incidence of HN with de novo internal neoplasms developing at earlier time-points than in those transplanted years ago".
"Risk factors for tumor development include alcohol, HCV and possibly strong immunosuppression".